Vignettes

Developed for practical use: below you find a collection of practical examples and use-cases, the so-called rpact vignettes.

In addition to these public open access vignettes, our RPACT SLA customers have access to exclusive vignettes on special topics such as the analysis of multi-stage data with covariates from raw data.

# Title Sort ascending Category Endpoint Summary
17 How to Create Summaries with rpact Utilities Categorical, Continuous, Survival

This R Markdown document provides many different examples that illustrate the usage of the R generic function summary with rpact. This is a technical vignette and is to be considered mainly as a comprehensive overview of the possible summaries in rpact.

19 How to Create One- and Multi-Arm Simulation Result Plots with rpact Utilities Categorical, Continuous, Survival

This R Markdown document provides many different examples for creating one- and multi-arm simulation result plots with rpact and ggplot2.

Power simulation, Multi-arm, Planning
18 How to Create One- and Multi-Arm Analysis Result Plots with rpact Utilities Categorical, Continuous, Survival

This R Markdown document provides many different examples for creating one- and multi-arm analysis result plots with rpact and ggplot2.

Analysis
10 How to Create Admirable Plots with rpact Utilities Categorical, Continuous, Survival

This R Markdown document provides many different examples for creating plots with rpact and ggplot2, e.g. the plot argument type will be illustrated.

Sample size, Power simulation, Power
4 Designing Group Sequential Trials with Two Groups and a Survival Endpoint with rpact Planning Survival

This R Markdown document provides examples for designing trials with survival endpoints using rpact.

2 Designing Group Sequential Trials with Two Groups and a Continuous Endpoint with rpact Planning Continuous

This R Markdown document provides examples for designing trials with continuous endpoints using rpact.

3 Designing Group Sequential Trials with a Binary Endpoint with rpact Planning Categorical

This R Markdown document provides examples for designing trials with binary endpoints using rpact.

26 Delayed Response Designs with rpact Planning Categorical, Continuous, Survival

This R Markdown document provides a brief introduction to group sequential designs with delayed responses as proposed by Hampson and Jennison (2013). It is shown how this is implemented in rpact. Examples for designing trials with delayed responses using the software are provided. We also describe an alternative approach that directly uses the α-spending approach to derive the decision boundaries.

1 Defining Group Sequential Boundaries with rpact Planning Categorical, Continuous, Survival

This R Markdown document provides example code for the the definition of the most commonly used group-sequential boundaries in rpact.

8 Defining Accrual Time and Accrual Intensity with rpact Utilities Survival

This R Markdown document provides a technical view on the different alternatives to define accrual time and accrual intensity with rpact.

Events

Presentation for the U.S. Food and Drug Administration (FDA), March 3, 2022, 9:00am - 11:00am…

03
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Online Training Course for PPD, January 13, 2022.

13
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